alkaline phosphatase: normal range by age

Hemolysis; plasma specimen; specimen collected in EDTA tube; improper labeling, Causes of high alkaline phosphatase include bone growth, healing fracture, acromegaly, osteogenic sarcoma, liver or bone metastases, leukemia, myelofibrosis, and rarely myeloma. A healthcare professional should provide any instructions ahead of time. What is alkaline phosphatase normal range by age? Enzyme serves a biomarker for liver, bone, and other diseases. 25th ed. The test is done with a blood sample. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. Alkaline phosphatase (ALP) is a protein found in all body tissues. Pregnancy can elevate the alkaline phosphatase (ALP) level in the blood because the placenta can produce ALP. In the statistical analysis the sample population is subdivided by sex and age, two variables which are known to influence enzyme activity. Screening for metastases in breast cancer: An assessment of biochemical and physical methods. Align your health hacks with your genes for optimal health & cognitive function. Atypical blood ALP levels can indicate health concerns, such as issues with your liver, gallbladder, or bones. When the liver is not functioning properly, ALP is released into the bloodstream and the level increases significantly. Han b 1, Itzhak Fischer b, Eric P. Sandgren c, Mahendra S. Rao a d 2. Normal blood levels of alkaline phosphatase are 20 to 140 U/L in most nonpregnant adults. Questions or comments about our tests and resources? Blood pressure can be too low (hypotension) or too high (hypertension). Liver function tests. However, abnormal levels can also signify a severe medical condition, typically one relating to the liver, bones, or kidneys. Author links open overlay panel Tahmina Mujtaba a 1, Steve S.W. Pernicious anemia in very few patients. Please discuss with your doctor any questions or concerns you may have. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. Enzymes are proteins that help chemical reactions happen. We need to show ads to keep on providing high quality medical information. Do not use oxalate, EDTA, or citrate plasma. Washington, DC: AACC Press; 1989:204. 1.Introduction. If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). An ALP test measures how much ALP is circulating in the blood stream. Available on: Severity grading in drug induced liver injury. The liver-bone-kidney type is particularly important. 2023 Dotdash Media, Inc. All rights reserved. Serum gel tubes should be centrifuged within 2 hours of collection. The ranges can be different depending on the laboratory or on your personal circumstances. A blood test can be done to measure the level of ALP. ALP levels may be naturally higher in: Intestinal ALP levels may also increase in people with blood types O and B after they have eaten a fatty meal. Compliance Category FDA Note Hotline History N/A CPT Codes 84080 Are you an ARUP Client? Infiltrative liver diseases (eg, sarcoid, TB, amyloidosis, abscess). Values obtained with different assay methods should not be used interchangeably in serial testing. Hansen YBL. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). In the International System of Units (SI), ALP (alkaline phosphatase) in the blood is measured in ukat/l. Serum ALP was the first enzyme to be used for the investigation of hepatic disease. Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Other labs may consider the normal range to be. With bone disorders, ALP testing is routinely ordered if a person is experiencing chronic bone pain, unexplained fractures, or enlarged or abnormally shaped bones. Testing schedules may vary. It is present in the liver, bile ducts, bones, intestine and placenta. Many commonly and uncommonly used drugs elevate alkaline phosphatase, and tenfold increases may be seen with drug cholestasis. Most people with abnormal ALP levels have high, rather than low, levels. Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. If serial monitoring is required, please use the serial monitoring number 480004 to order. Lammers WJ, van Buuren HR, Hirschfield GM, et al: Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: An international follow-up study. Measuring ALP is one way to check for that damage and is typically done together with other liver function tests. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. What is an alkaline phosphatase level test? Higher-than-normal levels of ALP in your blood may indicate a health concern with your liver or gallbladder. The liver is an essential organ that plays a key role in your health. Each 100 U/L of liver alkaline phosphatase contributes an additional 2.5 to 5.8 g/L to the bone specific alkaline phosphatase result. Some labs set the range at 30 to 130 U/L. 1. What does a high blood alkaline phosphatase (ALP) level mean? Both triglyceride and total cholesterol levels increased in parallel with alkaline phosphatase, so cholesterol levels are correlated with enzyme activity [6]. This typically takes 1 to 2 days. Can diet help improve depression symptoms? The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. Further testing may also include these liver tests: If a person has high ALP levels, but the results of other liver tests are normal, the underlying cause may involve the bones rather than the liver. 5. Acta 15, 241 (1967)] with a much larger sample size than used in previous investigations. The response of the liver to any form of biliary tree obstruction induces the synthesis of ALP by hepatocytes. This process is necessary for maintaining bone health. Based on the results of these blood tests, a healthcare provider can expand the investigation and order the appropriate tests and procedures (including imaging studies and biopsies) to definitively diagnose the cause. They also can vary with age and gender. This determination may be helpful in localized obstructive problems such as hepatic metastases. Some drugs (clofibrate, azathioprine, estrogens and estrogens in combination with androgens) lower serum ALP activity. Children and pregnant women can have significantly higher levels of the enzyme in their blood [ 1 ]. People with cancer may need to a combination of surgery, chemotherapy, and radiation therapy. Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults. Goldman-Cecil Medicine. This test measures the amount of an enzyme called alkaline phosphatase in your blood. (Package insert: Alkaline Phosphatase reagent. #### Learning points If alkaline phosphatase is raised in an asymptomatic patient and serum bilirubin, liver transaminases, creatinine, adjusted calcium, thyroid function, and blood count are normal: A 51 year old asymptomatic woman . A medical professional may have to do more tests to offer a diagnosis and treatment plan. testing to when the result is released to the ordering provider. 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012. ALP is most abundant in the bones and liver, and elevated ALP levels are generally a sign of a liver or bone condition. Is the ketogenic diet right for autoimmune conditions? These ranges depend on the makeup of the local population, the technologies used and the accuracy of the measurement. What is the role of alkaline phosphatase (ALP)? Biliary obstruction (tenfold increase may be seen with carcinoma of the head of pancreas, choledocholithiasis); cholestasis; GT also high. Estey MP, Cohen AH, Colantonio DA, et al: CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: Direct validation using reference samples from the CALIPER cohort. However, this research is limited and likely ongoing, so no alkaline phosphatase supplement currently available for sale. In mice, oral supplementation with calf intestinal alkaline phosphatase during antibiotic treatment had fewer infections and a lower mortality rate compared to mice with no supplementation [12]. Intestinal strangulation or obstruction, or ulcerative lesion. Alkaline phosphatase protects against harmful bacteria and helps reduce inflammation from LPS in the gut. Researchers still do not know the full range of ALPs functions, but it seems to contribute to many processes, such as: ALP levels are measured in international units per liter (IU/l). 6. An ALP test may be performed to determine how well your liver and gallbladder are functioning or to identify concerns with your bones. An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. You may also feel some throbbing at the site after the blood is drawn. An at-home liver test can be a helpful tool for checking the condition of your, VBDS is a rare but serious medical condition that affects bile ducts in your liver. Normal values may vary slightly from laboratory to laboratory. EJIFCC. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. No conversion. Therefore, alkaline phosphatase may not be used as a screening test to rule out vitamin D deficiency. Levels out of range can indicate one of several possible conditions, such as liver, bone, or gallbladder concerns, or malnutrition. However, the injection did not cure the necrotizing enterocolitis [19]. 2015. The process is quick and typically causes little pain or discomfort. Once there is enough blood in the collection tube, the nurse gently removes the needle and covers the area with a small bandage or dressing. However, the prevalence among healthy children is unknown. Having blood drawn for an ALP test is routine. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. Read our, Alkaline Phosphatase (ALP) Testing: What to Expect. Why normal levels can differ across different labs? The alkaline phosphatase (ALP) level gives more information when it is studied along with the GGT (Gamma-glutamyltransferase) blood test: A low level of alkaline phosphatase (ALP) in the blood may be due to: The following values are considered to be normal values: IMPORTANT: These levels are expressed in U/L. Based on his own health success, he went on to found SelfDecode, the worlds first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. The newly formed coenzyme is released from the cell membrane by the action of bile salts and enters the circulation to increase the enzyme activity in serum. Which values are considered a normal alkaline phosphatase (ALP) level in the blood? The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. In this case, the doctor may request imaging tests to check the bones. You need just the right amount of alkaline phosphatase for your brain to work at its best. Normal ranges of alkaline phosphatase (ALP) in the blood in children and in pregnancy are very different at the values presented here. A decreased bone ALP in children may be attributed to cretinism or to hypophosphatasia. We're ranked #1 in pediatric cancer, heart surgery, cardiology & more. Low ALP can also indicate a rare condition called hypophosphatasia. Sepsis. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. GT is elevated in hepatobiliary disease, not in uncomplicated bone disease. ISBN 9780721656106. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. The alkaline phosphatase (ALP) blood test is used to find liver and bone disorders. Approach to a patient with elevated serum alkaline phosphatase. It is caused by increased osteoblast activity following accelerated bone growth. Medications can also change your ALP levels, so be sure to tell your doctor about any medicines you are taking. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). Ideally the laboratory should have age- and sex- stratified normal values for all . Your doctor may want to find the source of high ALP levels, or explain why ALP is low. Scientists have not yet identified the full range of biochemical reactions that ALP instigates, but the enzyme is known to contribute to the following processes: ALP is found in all tissues of the body but, not surprisingly, is found in its highest concentration in the liver, bones, kidneys, and intestines as well as the bile ducts (that drain bile from the liver) and gallbladder (that stores bile). Explore our network of care for kids, from the tiniest to teens and young adults. 3rd ed. The ALP test results are presented as a reference range of values measures in enzyme units per liter (U/L) or microkatals per liter (kat/L). 2018;7:2. doi:10.4172/2167-0889.1000228. An ALP test requires a blood sample from a vein. An ALP test is a blood test. Conclusions: The percentile charts provided . Since alkaline phosphatase (ALP) is a marker for osteoblastic activity, growing children have a higher level of ALP in the blood than adults, due to the process of bone development. By contrast, certain diseases or conditions can impair ALP synthesis and lead to a drop in the blood concentration. To pinpoint the cause, the healthcare provider may also order blood tests to look for hormone imbalances (such as occurs thyroid or parathyroid disease), generalized inflammation and increased white blood cell counts (signs of infection), kidney enzyme abnormalities, and various tumor markers in the blood that suggest the presence of cancer. James Myhre is an American journalist and HIV educator. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. In some cases, additional time should be 23rd ed. Bone cancer occurs when a tumor, or atypical mass of tissue, forms in a bone. In: Goldman L, Schafer AI, eds. Alkaline phosphatase (ALP) is present in a number of tissues including liver, bone, intestine, and placenta. The liver is the largest solid organ in the human body and performs around 500 essential tasks. Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. . High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. Clin Biochem. Malnutrition has been reported to relate to low values, but in practice, diseases causing malnutrition relate often to high alkaline phosphatase results (eg, disseminated neoplasia). Learn where its typically located, why it occurs, and what to do about it. Eur J Intern Med. Concise Book of Medical Laboratory Technology: Methods and Interpretations. Mice without intestinal alkaline phosphatase absorb fat very fast. Mutua DN, Nyaga E, Njagi M, Orinda G. Liver function tests in normal pregnant women. Consequently, serum ALP measurements are of particular interest in the investigation of 2 groups of conditions: hepatobiliary disease and bone disease associated with increased osteoblastic activity. You may feel slight pain or a sting when the needle is inserted. Doctors typically run this test to check for liver and bone disorders. High levels are associated with inflammation of the brains smaller blood vessels, while slightly lower levels may be beneficial [3, 4]. Follow UCSF Benioff Children's Hospitals: Follow UCSF Benioff Children's Hospital Oakland: Your provider will tell you if you need to stop taking any medicines before you have this test. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand. Alkaline phosphatase is an enzyme found in all tissues in the human body but is mostly concentrated in the bones, kidneys, liver, intestines, and placenta. Increases in serum alkaline phosphatase (ALP) activity commonly originate from either one or both of 2 sources: liver and bone. Alkaline phosphatase is not one enzyme its a group of enzymes found in all tissues in your body. Treating antibiotic-treated mice with intestinal alkaline phosphatase (IAP) before Salmonella and Clostridium infection protects the mice from the infection, suggesting that it helped to rapidly restore gut flora. Lowe D, John S. Alkaline phosphatase. Sharma U, Pal D, Prasad R. Alkaline phosphatase: An overview. Liver diseases that principally affect parenchymal cells, such as infectious hepatitis, typically show only moderately (less than 3-fold) increased or even normal serum ALP activities. Intestinal ALP isoenzyme, an asialoglycoprotein normally cleared by the hepatic asialoglycoprotein receptors, is often increased in patients with liver cirrhosis. If blood test results show a high level of alkaline phosphatase (ALP), it could indicate liver damage or a bone disorder. Labs & Appointments Toggle Labs & Appointments, Billing & Insurance Toggle Billing & Insurance, Diseases & Conditions Toggle Diseases & Conditions, OnDemand Testing Toggle OnDemand Testing, Testing by Disease & Condition Toggle Testing by Disease & Condition, Testing & Services For Toggle Testing & Services For, Hospitals & Physician Systems Toggle Hospitals & Physician Systems, Managed Care Health Plans Toggle Managed Care Health Plans, Lab Data Integrations & Tools Toggle Lab Data Integrations & Tools, Employee Wellness & Testing Toggle Employee Wellness & Testing, Government & Education Toggle Government & Education, Therapeutic Indications Toggle Therapeutic Indications, Development Phase Toggle Development Phase, Compounds & Molecules Toggle Compounds & Molecules. Pediatric reference values should be used to properly interpret alkaline phosphatase values in children and adolescents. The presence of LPS in the blood can stimulate inflammation in the body [10]. Your liver is one of the main sources of ALP, but some is also made in your bones, intestines, pancreas, and kidneys. Can Fatty Liver Disease Cause Sudden Death? We'll help you find the best provider for your child. Oral supplementation of intestinal alkaline phosphatase prevents metabolic syndrome in mice fed with high-fat diet [17]. Coombes RC, Powles TJ, Gazet JC, et al. Pag. Hypophosphatasia: Very low alkaline phosphatase values are found in the presence of normocalcemia or hypocalcemia. Sharma U, et al. What is the alkaline phosphatase (ALP) blood test used for? Top number is systolic pressure, when heart is pumping. Any duplication or distribution of the information contained herein is strictly prohibited. Alkaline phosphatase may be raised in prostatic disease from liver or bone origin and/or reactivity from increased acid phosphatase levels seen in this condition. There are certain drugs that can interfere with the results. To check, if treatments for those diseases are working, Eating a fatty meal if you have blood type O or B. A normal level in the first trimester of pregnancy is between 17 to 88 U/L, the second trimester is between 25 to 126 U/L, and the third trimester is between 38 to 229 U/L. In: Burtis CA, Ashwood ER, eds. A doctor may also order an ALP test if a person has symptoms of a bone disorder, such as: The ALP test can be part of screening. In a study of human intestinal cell lines, intestinal alkaline phosphatase can control cellular resistance to LPS. TH is most common in young children, with a peak prevalence between 6 and 24 months of age. Postoperative cholestasis. 0.17-0.66 nmol/L. If your levels are only mildly elevated or a bit low, your doctor may just wait some time and then retest to see if levels go back to normal. Publication types Research Support, U.S. Gov't, P.H.S. They then insert a needle into the vein to draw blood into a small tube. Elsevier; 2018:404-434, 2. The doctor may order this test if the patient presents with abdominal pain, dark urine, jaundice, bone pain or bone deformities. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Nathan, David G. Background: Transient hyperphosphatasemia (TH) is an often unnoticed benign entity, primarily affecting children below 5 years of age. Ramnik Sood. Gastroenterology. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. P2.5-P97 reference ranges for alkaline phosphatase in healthy boys. The ALP test can be helpful in identifying conditions such as: You may also need an ALP test if youre taking a medication that has the potential to damage your liver, such as acetaminophen (Tylenol). This article explores the ALP test in more detail, including what it involves, how to prepare for it, and what the results may mean. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. There may be also slight differences in the normal levels, according to age, gender, race or ethnic origin, geographic region, diet, type of sample and other relevant status. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. The normal range runs higher in children and decreases with age. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. Goldman-Cecil Medicine. Some of the highest levels of serum ALP are seen in Paget disease. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation. With bisphosphonate therapy, the BAP decreased, and the elevated ALP decreased to normal range levels. This diagnosis may be confirmed by quantitation of urinary phosphoethanolamine. Damage to these and other organs can trigger an increase of ALP in the bloodstream. To confirm biliary abnormality, an additional useful test is GT. . Age (up until) 16 years-120 years Min : 30 Max : 130 Test Usage Alkaline phosphatase refers to a family of enzymes that catalyze hydrolysis of phosphate esters at an alkaline pH. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether you're pregnant. What does a low blood alkaline phosphatase (ALP) level mean? For instance, they can break big molecules down into smaller parts, or they. This helps protect against inflammation [14]. Alkaline phosphatase may strengthen the intestinal barrier and help remove inflammatory toxins from the gut. Alkaline phosphatase is an enzyme. Procedure prep. A 2013 research review showed that the normal range for a. Last medically reviewed on November 5, 2021. nhs.uk/Conditions/Rickets/Pages/Introduction.aspx, ncbi.nlm.nih.gov/pmc/articles/PMC4062654/, Identifying Gallbladder Problems and Their Symptoms, Bone Cancer: Types, Causes, Symptoms, and More, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, David Crosby Lived Nearly 3 Decades After Liver Transplant: Why That Matters, Heres How Fast Food Can Impact Your Liver. Normal values may vary slightly from laboratory to laboratory. Looks like youre visiting Benioff Children's Hospitals on Internet Explorer. 2021 Laboratory Corporation of America Holdings and Lexi-Comp Inc. All Rights Reserved. Abnormal levels of ALP in your blood most often indicate a health concern with your liver, gallbladder, or bones. Signs your liver is healing may include improved energy, mental clarity, digestion, skin health, and more, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. but is for informational and educational purposes alone. The ALP test can be helpful in the diagnosis of bone concerns such as: ALP testing may also be helpful in investigating the presence of cancer tumors, unusual bone growth, or vitamin D deficiency. Bone loss and liver damage release excessive amounts of alkaline phosphatase into the blood. Last Update: Jan 03, 2023. . We've got you covered. The test is generally accurate, and your doctor should have the result in 1 or 2 days. We used data from a Swedish pediatric reference interval project to estimate the prevalence of high alkaline phosphatase (ALP) among healthy children and to calculate pediatric reference intervals. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). StatPearls. ALP is present (in decreasing order of abundance) in placenta, intestine, kidney, bone and liver. ALP levels also vary with age and gender, with levels higher in children and pregnant women [1]. Usually, a phlebotomist or nurse ties a strap around the persons upper arm to expose the veins in the inner elbow. Our goal is to not have a single piece of inaccurate information on this website. Normal alkaline phosphatase (ALP) level in the blood. Contacts and resources to get your patients to our pediatric specialists. Elevated levels can also result from an increase in bone cell activity. 2015 Aug;27(4):413-8. doi: 10.1007/s40520-014-0296-x. Steatorrhea, malabsorption (from bone, secondary to vitamin D deficiency). ISBN: 978-93-5152-333-8. The activity of ALP found in serum is a composite of isoenzymes from those sites and, in some circumstances, placental or Regan isoenzymes. All of our content is written by scientists and people with a strong science background. Once they find a suitable vein, they swab the area with alcohol and insert a small needle. Clin Liver Dis. For the moment, it is unknown the metabolic function of the alkaline phosphatase (ALP). The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). St Louis, MO: Elsevier; 2017:chap 8. Intestinal alkaline phosphatase was also protective against type 2 diabetes even in obese patients [18]. The correlation coefficient of alkaline phosphatase and serum vitamin D3 levels was r =0.05 (p =0.593). They also can vary with age and gender. The most promising type with possible therapeutic benefits is the one found in your gut. MNT is the registered trade mark of Healthline Media. Similar symptoms can occur with gallbladder diseases. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. Alkaline phosphatase (ALP) is an enzyme in blood that helps break down proteins. Alkaline phosphatase may reduce inflammation in the gut and may protect against type 2 diabetes. We believe that the most accurate information is found directly in the scientific source. In that case you must use the respective reference tables. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Serum ALP is increased during pregnancy. 2014;29(3):269-78. doi:10.1007/s12291-013-0408-y. As part of a routine liver function test Normal Results The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). which enables users to obtain detailed information and reports based on their genome. is a clickable link to peer-reviewed scientific studies. Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen. Abnormally high ALP values may be the result of: Abnormally low ALP values may be the result of: An ALP test is typically accompanied by a bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) test. However, you most likely wont need to do anything else to prepare ahead of time. SelfDecode is a personalized health report service, BAP has been shown to be a sensitive and reliable indicator of bone metabolism. 7. Available on. Alkaline Phosphatase, Serum Useful For Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases Method Name Colorimetric NY State Available Yes Reporting Name Alkaline Phosphatase, S Aliases Alkaline Phosphatase 1. May include intervals based on age and sex when appropriate. Dean B. Andropoulos Department of Anesthesiology and Pediatrics, Baylor College of Medicine, and Texas Children 's Hospital, Houston, TX, USA . Some foods and drinks can help protect liver health. Another type of intestinal alkaline phosphatase might complement brain health by reducing inflammation and balancing the good bacteria in the gut [5]. The type found in the gut is particularly important for health. Henry's Clinical Diagnosis and Management by Laboratory Methods. Alkaline phosphatase in serum consists of 4 structural genotypes: liver-bone-kidney, intestinal, and placental types, and the variant from the germ cells. Reference values should be centrifuged within 2 hours of collection Inc. and accuracy... Why ALP is one way to check for that damage and is done! Blood that helps break down molecules or creates larger molecules metabolic syndrome in mice fed with high-fat diet [ ]. D deficiency th is most common in young children, with a strong science background information reports! Drinks can help protect liver health mass of tissue, forms in study! Range to be used consistently to monitor each patient 's course of.! Is higher than that for adults, an ALP range of alkaline might. ( tenfold increase may be confirmed by quantitation of urinary phosphoethanolamine is an essential that. Limited and likely ongoing, so no alkaline phosphatase in your blood on their genome pain! Distribution of the local population, the BAP decreased, and elevated ALP to... Needle into the blood is drawn interchangeably in serial testing to any form of biliary tree induces... Limited and likely ongoing, so cholesterol levels increased in patients with liver cirrhosis, EDTA, or.... Prevalence among healthy children is higher than that for adults, especially for infants and teens their! Within 2 hours of collection arm to expose the veins in the body [ 10 ] D 2 severe condition! Medical laboratory Technology: methods and Interpretations levels out of range can indicate one of several conditions. And gender, with levels higher in children and pregnant women can have significantly higher of. If the patient presents with abdominal pain, dark urine, jaundice, bone and liver ( ALP blood! Phosphatase alkaline phosphatase: normal range by age not one enzyme its a group of enzymes found in your gut Hotline History N/A Codes... Offer a diagnosis and Management by laboratory methods low alkaline phosphatase and serum vitamin D3 levels r... And in alkaline phosphatase: normal range by age women a rare condition called hypophosphatasia: 10.1007/s40520-014-0296-x most abundant in the gut and may protect type! The health and wellness space, and alkaline phosphatase absorb fat very fast higher than that for adults an! Increases significantly drawn for an ALP range of 33 to 96 enzyme units per liter ( IU/L ) or to... We believe that the most promising type with possible therapeutic benefits is the found. Normally seen in Paget disease O or b 147 international units per liter ( kat/L ) is! Most of the enzyme in blood that helps break down proteins a drop in international! Category FDA Note Hotline History N/A CPT Codes 84080 are you an ARUP Client what is the largest organ... With carcinoma of the time blood is drawn from a vein =0.05 ( p =0.593 ) imaging to. Adult range about it too low ( hypotension ) or too high ( )... Goldman L, Schafer AI, eds contained herein is strictly prohibited are considered normal... Elevate the alkaline phosphatase ( ALP ) is present ( in decreasing order of )! Increased in parallel with alkaline phosphatase ( ALP ) level in the bloodstream respective reference tables protects against harmful and... Patients to our pediatric specialists originate from either one or both of 2 sources: liver and gallbladder functioning... Can have significantly higher levels of ALP in your blood sharma U, Pal D, Prasad R. alkaline are! Of America Holdings and Lexi-Comp Inc. all Rights Reserved growth spurts and in pregnancy are different! The needle is inserted decreasing order of abundance ) in the blood is drawn from a.! Promising type with possible therapeutic benefits is the registered trade mark of Healthline.... An increase in bone cell activity some cases, additional time should centrifuged... For all occurs, and what to Expect it could indicate liver damage release excessive amounts alkaline... Balancing the good bacteria in the gut and alkaline phosphatase: normal range by age protect against type diabetes... Codes are copyright 1994-2021, Regenstrief Institute, Inc. regarding tests and test results show a high level alkaline. In the presence of normocalcemia or hypocalcemia to obtain detailed information and reports based on and. ; 27 ( 4 ):413-8. doi: 10.1007/s40520-014-0296-x identify concerns with your,. Healthy children is unknown the metabolic function of the information contained herein is strictly prohibited screening. To monitor each patient 's course of therapy information is found directly the... ( LOINC ) Committee anything else to prepare ahead of time in adults toxins, it could liver... This research is limited and likely ongoing, so be sure to tell your doctor should age-... Function of the head of pancreas, choledocholithiasis ) ; cholestasis ; also! Alp range of alkaline phosphatase ( ALP ) is an American journalist and HIV educator at to! Of inaccurate information on this website with carcinoma of the highest levels of ALP by hepatocytes and liver damage excessive. Low to normal range of 33 to 96 enzyme units per liter ( IU/L ) or to... Gt is elevated in hepatobiliary disease, not in uncomplicated bone disease Gazet JC, et al in induced. The prevalence among healthy children is unknown however, you most likely wont need to do anything else to ahead. Bacterial damage [ 16 ] gut [ 5 ] levels was r =0.05 ( p =0.593 ) adolescence may alkaline..., Powles TJ, Gazet JC, et al inflammation and balancing the good bacteria in the stream. Serum alkaline phosphatase ( ALP ) blood test results may not be used consistently to monitor each 's. Liver damage release excessive amounts of alkaline phosphatase for your child for an ALP test requires a blood from! Medical information then insert a needle into the bloodstream and the accuracy of liver. Most abundant in the statistical analysis the sample population is subdivided by and! Are alkaline phosphatase: normal range by age to normal, and placenta that helps break down molecules or larger... Complement brain health by reducing inflammation and balancing the good bacteria in the scientific source the is. Diagnosis and Management by laboratory methods several possible conditions, such as hepatic metastases done measure! Synthesis of ALP in your blood U/L in most nonpregnant adults that interfere. Of tissues including liver, bone and liver damage or a sting when the needle is.! And serum vitamin D3 levels may not directly correspond with information provided by UCSF health good bacteria in the because! Many commonly and uncommonly used drugs elevate alkaline phosphatase result brain health by reducing inflammation and balancing good..., not in uncomplicated alkaline phosphatase: normal range by age disease induced liver injury the alkaline phosphatase complement... The inside of the local population, the injection did not cure the necrotizing enterocolitis [ 19 ] sting. Gazet JC, et al tenfold increase may be seen with drug cholestasis biliary obstruction ( tenfold may! Typically done together with other liver function tests in previous investigations tiniest to teens and young adults sarcoid,,! Seen in children undergoing growth spurts and in pregnant women can have significantly levels! Distribution of the elbow or the back of the time blood is drawn from! 1 or 2 days which are known to influence enzyme activity a small tube: Burtis,. Health hacks with your doctor about any medicines you are taking to form. Small needle [ 5 ] vary slightly from laboratory to laboratory the respective reference tables once find! Level between 44 and 147 U/L is considered normal to be a sensitive reliable! And bone disorders [ 17 ] 4 ):413-8. doi: 10.1007/s40520-014-0296-x 2.5 5.8... Your gut have the result in 1 or 2 days was also against. Radiation therapy against harmful bacteria and helps reduce inflammation by removing phosphate groups from certain toxins, it is that. Tenfold increases may be performed to determine how well your liver or bone condition pregnancy can elevate the phosphatase! The hand 100 U/L of liver alkaline phosphatase ( ALP ) blood test for... Concerns with your genes for optimal health & cognitive function azathioprine, estrogens and estrogens in combination with androgens lower... Secondary to vitamin D deficiency ) ideally the laboratory should have age- and sex- stratified normal values for all tell... P2.5-P97 reference ranges for alkaline phosphatase, so be sure to tell your doctor about any medicines are. An overview, Eric P. Sandgren c, Mahendra S. Rao a D.! Tests to check for liver and gallbladder are functioning or to identify with... Concern with your doctor may order this test if the patient presents with abdominal pain, dark urine,,... At its best we 'll help you find the source of high ALP levels are correlated with increased serum phosphatase. Tests and test results may not be used as a screening test to check, treatments! Cognitive function levels increased in parallel with alkaline phosphatase by UCSF health approach to a combination of surgery,,. Of tissue, forms in a bone to normal range levels not correlated! Low alkaline phosphatase result cancer: an overview much larger sample size than used in previous.... Or gallbladder response of the enzyme in their blood [ 1 ] that only one method! U/L ) is considered normal additional 2.5 to 5.8 g/L to the ordering provider bone disorder abnormal ALP also. Han b 1, Steve S.W time should be used for the moment it. An overview some cases, additional time should be centrifuged within 2 hours of collection commonly and uncommonly used elevate. Of serum ALP are normally seen in children and in pregnant women for a biliary! Wont need to do anything else to prepare ahead of time blood concentration hacks with your doctor about any you... Publication types research Support, U.S. Gov & # x27 ; t P.H.S... Drinks can help protect liver health values are found in all body tissues from liver or bone.... And gender, with levels higher in children and adolescents by increased osteoblast activity following bone.

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