2002 Sep; 132(3):441-9. Hepatology. 2011 Jan; 53(1):96-105. Semin Liver Dis. Gastroenterology. 2015 Jul; 22(7):512-8. Gut. Am J Physiol Gastrointest Liver Physiol. Front Physiol. Hepatology. 2008 Feb; 47(2):677-85. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. 2022 08; 42(3):233-249. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. Role of Gut Microbiota in Liver Disease. 2016 07; 111(7):986-94. Int J Mol Sci. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Am J Physiol Heart Circ Physiol. 2010 Oct; 8(10):891-8, 898.e1-2. J Clin Invest. PLoS One. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. 1999 Mar; 31(2):173-9. Gut. Surgery. 2015 Apr; 61(4):1239-50. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. J Hepatol. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Cancer Res. 2009 Nov; 58(11):1517-27. Cell Death Differ. Gastroenterology. 1998 Jul 01; 92(1):320-8. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. 1989 Feb 16; 337(6208):661-3. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Aliment Pharmacol Ther. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Hepatology. Mol Cell Biol. Cell Death Differ. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. 2002 Jul; 283(1):G204-11. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. J Biol Chem. Am J Physiol. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. He did not respond to inewsource s interview request. J Hepatobiliary Pancreat Sci. 2003 Feb; 124(2):445-58. 2003 Apr; 38(4):468-75. J Hum Nutr Diet. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. 1998 Jul; 43(7):1454-64. Science. Liver fibrogenesis: a new role for the renin-angiotensin system. 2006 Jul; 131(1):272-5. 2005 Apr; 115(4):849-59. 2022 07; 10(7):e1953. Am J Physiol Gastrointest Liver Physiol. 2015 May; 31(3):184-91. 2005; 23(3-4):255-63. J Biol Chem. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 1998 Oct; 27(3):192-8. Arch Biochem Biophys. 2012 Sep; 143(3):765-776.e3. 2021; 16(12):e0260721. Hepatology. Am J Gastroenterol. 2004 Jan; 2(1):9-13. Yang L, Magness ST, Bataller R, Rippe RA. Int Psychogeriatr. 2021; 8:790032. Hum Gene Ther. 1998; 8(3-4):283-5. J Clin Invest. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. J Hepatol. 2019 01; 17(2):218-230. 2000 Apr 21; 275(16):11814-23. Liver Int. J Immunol. 1980 Apr 03; 302(14):765-9. 1998 04; 274(4):G669-76. Leadership - Institute for Diabetes and Metabolic Health - UC San Aliment Pharmacol Ther. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2017 10 10; 114(41):10808-10809. JCI Insight. Yale J Biol Med. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. 1990 Nov; 26(11):1011-23. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. 1998 Aug 10; 1366(1-2):177-96. J Hepatol. 1990; 24:352-8. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. To see the data as text. J Gastroenterol Hepatol. Gastroenterology. Cell Metab. Am J Physiol. 2006 Oct; 21 Suppl 3:S84-7. 2002 Aug; 36(2):315-25. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Expression of collagen genes in the liver. 2007 Jun; 22 Suppl 1:S73-8. 2015 Sep; 39 Suppl 1:S75-9. Mol Endocrinol. Hepatology. 1999 Oct; 18(10):751-61. 2012 Nov; 13(11):1072-82. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Alcohol Clin Exp Res. Proc Natl Acad Sci U S A. 2000 Jan 15; 28(2):641-7. People who share similar concepts with this person. Methods Mol Biol. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Methods for analyzing c-Jun kinase. 2003 Jul; 39(1):38-46. Proc Am Thorac Soc. J Gastroenterol Hepatol. Clin Res Hepatol Gastroenterol. 2013 Apr; 144(4):661-3. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. 2012 Jun; 10(6):575-80. Mechanisms of hepatic toxicity. Differentiation. Cancer Detect Prev. Am J Physiol Cell Physiol. 2020 May 05; 56(5). 2011 Jul; 31(6):762-72. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. 1997 May; 25(5):1128-35. We lose people all of WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Cloning of murine ferrochelatase. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. 2007 May; 132(5):1937-46. Fibrogenesis of parenchymal organs. 2021 08; 74(2):667-685. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Hepatology. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 2010 Feb 25; 3:39-47. Gastroenterology. Note that an individual publication can be assigned to more than one field. Mechanisms of fibrogenesis. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Biofactors. J Exp Med. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. 1994 Dec 09; 269(49):30789-97. Hepatology. 2002 Nov; 70(11):6294-301. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. 2015 Feb; 21(2):159-65. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2016 Aug; 38(4):291-302. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. 1996 Nov; 271(5 Pt 1):G780-90. 1996 Sep; 24(3):670-6. 2003 Jan 01; 8:d69-77. 2009 Sep; 50(3):929-38. The enteropathy of prostaglandin deficiency. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Therapeutic strategies for hepatic fibrosis. Medicina (Kaunas). Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Hepatology. 2009 Jan; 130(1):16-26. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. The future of gastroenterology and gastroenterology. J Gastroenterol Hepatol. 2001 Apr 10; 103(14):1920-7. Gastroenterology. David has 2 jobs listed on their profile. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. 2010; 2010:362847. Deletion of the ferrochelatase gene in a patient with protoporphyria. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. J Bone Miner Res. To return to the graph. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. 1985 Apr; 5(4):684-91. 2014 May; 146(6):1513-24. Gastroenterology. Hepatology. Gastroenterology. 2020 12; 72(6):2182-2196. 2017 01; 65(1):78-88. Proud to be part of UC San Diego and UC San Diego Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Hepatology. 2008 Jul; 255(7):993-1000. 2008 Jun; 118(6):2121-31. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. 1995 Oct; 269(4 Pt 1):G591-9. Hepatology. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Gastroenterol Hepatol (N Y). Gene expression profiles during hepatic stellate cell activation in culture and in vivo. J Cardiovasc Med (Hagerstown). Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. 2008 Aug; 42(5):349-61. 2003 Oct; 125(4):1009. 2007 Jun 15; 462(2):266-72. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. 2012 Mar; 10(3):285-90.e1. Hepatology. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 2005 Jul 29; 280(30):27879-87. 2015 Nov; 22(11):1837-45. Mol Pharmacol. The origin of myofibroblasts in liver fibrosis. PLoS One. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. 2017 11; 15(11):1808-1810. 1998 Sep; 13 Suppl:S39-50. 2010 Oct; 16(10):1152-6. J Hepatol. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. 2001 Dec; 35(6):749-55. J Biol Chem. Proc Natl Acad Sci U S A. Aliment Pharmacol Ther. 2006 Nov; 26(9):1138-47. 2005 May; 41(5):1046-55. 2020; 4(5):561-580. Techniques to measure nucleic acid-protein binding and specificity. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. Hepatology. 1987 Sep; 79(3):449-56. Clin Gastroenterol Hepatol. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. J Neurol. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Hepatol Commun. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Moderate alcohol drinking: effects on the heart and liver. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 2014 Aug 12; 111(32):E3297-305. Gastroenterology. Hellerbrand C, Jobin C, Licato LL, Sartor RB. Is it the end of the line for the EMT? Integr Biol (Camb). Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Sp1 binding activity increases in activated Ito cells. Gastroenterology. Gastroenterology. 2000 Feb; 88(2):142-9. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Clin Gastroenterol Hepatol. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Hepatol Res. 2016 Feb 10; 19(2):227-39. Am J Physiol Gastrointest Liver Physiol. Altman Clinical and Translational Research Institute (ACTRI). After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. Stroke. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 2005 Jun; 42(6):850-9. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. J Biol Chem. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Gastroenterology. Biochim Biophys Acta. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. 2005 May; 41(5):1085-95. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 2021 08 01; 321(2):H435-H445. 1991; 10(3-4):452-5. 1990 Feb; 10(1):75-83. 2018 12; 15(12):785. Neurology. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. 2005 Nov; 29(11 Suppl):102S-109S. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. 2012 Mar; 27 Suppl 2:65-8. Immunol Res. 2003 Mar; 37(3):653-64. Proc Natl Acad Sci U S A. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 2021 07 20; 118(29). Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. Osawa Y. 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